The Lexus IS models provide a sporty driving experience while also offering a supple, quiet ride. The double-wishbone front suspension and multi-link rear suspension use high-strength steel and aluminum components to reduce unsprung weight. Sophisticated monotube shock-absorbers integrate multi-leaf linear control valves to optimize damping force, plus internal rebound springs for firmer body control without degrading ride comfort.

The all-wheel-drive system available for the IS 250 and IS 350 provides extra traction in diverse driving conditions. A planetary-gear center differential and a wet-type multi-disc clutch control front-to-rear power distribution. The system normally sends 70 percent of available power to the rear wheels to provide the performance advantages of a rear-drive car and will vary the torque-split ratio from 30:70 to 50:50 in response to driving conditions and driver input. The AWD system's electronic-control strategy takes inputs such as steering and throttle angle from driver activity combined with vehicle signals from wheel speed and yaw rate sensors.

Aiding the IS models' traction and stability is Vehicle Dynamics Integrated Management (VDIM). More advanced than other traction and stability systems, VDIM is designed to anticipate the onset of a vehicle skid or slide and help correct the situation with a combination of braking and throttle control. VDIM integration provides precise management for Electric Power Steering (EPS), Vehicle Stability Control (VSC), the Anti-lock Braking System (ABS), Brake Assist (BA), Electronic Brake force Distribution (EBD), and engine torque (via the electronically controlled throttle). The driver can disengage VSC via the "TRAC off" switch, which can be useful in certain situations.

The Lexus IS 350's brake system is equipped with larger ventilated front and rear rotors and aluminum four-piston front calipers. Standard all-season performance tires are 225/45R17 in front and 245/45R17 for the rear (225/45R17 on IS 250 and IS 350 AWD). Eighteen-inch wheels are available.