The Lexus IS models include a standard leather-trimmed interior with 10-way power front seats; some competitive vehicles make a leather interior optional. The numerous standard amenities in the IS models also include dual-zone automatic climate control with rear-seat vents and a pollen filter (plus a smog filter on Lexus IS 350), power moonroof with one-touch open/close and seven open-position settings, manual tilt-and-telescoping steering wheel, all power windows with automatic up/down feature and jam protection, HomeLink® and an auto-dimming rear-view mirror. The AWD models in addition feature standard heated seats. The SmartAccess keyless entry and push-button-start ignition allows the driver to keep the access fob in a pocket or purse.

The standard Lexus Premium Audio System features a six-disc, in-dash CD changer, 194 watts (max.) total power, 13 speakers, iPod®/USB connectivity, Bluetooth® hands free phone and music streaming and an integrated satellite radio receiver. The Automatic Sound Levelizer (ASL) maintains consistent sound levels at varying vehicle speeds.