Lexus makes personalizing the Lexus GX 460 easy for 2010 by offering a Convenience Package and a Comfort Plus Package, as well as making many of the packages' features available as stand-alone options. The Convenience Package includes electrochromic exterior mirrors with power retract, and Intuitive Parking Assist. The Comfort Plus Package includes semi-aniline leather; heated second-row outer seats; wood-trimmed steering wheel and shift knob; and three-zone automatic climate control.

The new-generation hard disc drive (HDD) navigation system is a standalone option for 2010 and features Voice Command casual language-based voice recognition system and Bluetooth phonebook download to enhance owner convenience. The available Mark Levinson Premium Audio system is the platinum standard for OEM mobile audio and for 2010 features 17 speakers, up from 14 in the 2009 model. The available Rear Seat Entertainment (RSE) system now includes two LCD screens, one in each of the front seat backrests. Three-zone automatic climate control for enhanced third-row passenger comfort is also available as a standalone option.

The newly available Wide-view Front and Side Monitor, which debuted on the 2009 LX 570 premium luxury utility vehicle, is designed to enhance visibility in tight settings, such as parking garages, and to help the driver view blind spots when pulling out of parking spaces into traffic, and stopped at intersections and T-junctions. The new available Intuitive Parking Assist helps the driver detect obstacles at the front, rear or corners of the vehicle and helps guide the GX into street or garage parking spaces.