The Adaptive Front-lighting System (AFS), standard on the Lexus GS 460 and optional for the GS 350, helps illuminate a curve as the driver steers into it. A Tire Pressure Monitoring system can detect a critical loss in pressure in one or more tires and alert the driver. The available Intuitive Park Assist (IPA) system uses ultrasonic sensors to detect objects close to the car's front and rear bumpers and alerts the driver accordingly. A steering-input sensor helps to better judge changes in distance to objects.

The Supplemental Restraint System (SRS) in the GS sedans includes variable-force front airbags for both the driver and front passenger. The GS features standard seat-mounted side airbags for the front seats, knee airbags for the driver and front passenger, and front and rear side-curtain airbags.

The rear back-up camera, included with the optional navigation system, automatically projects an image of what its lens can detect behind the vehicle onto the navigation screen when the vehicle is in reverse gear.

The optional Pre-Collision System (PCS) in the GS models can help mitigate the effects of an accident. A millimeter-wave radar sensor helps detect obstacles in front of the car, while vehicle speed, steering angle and yaw-rate inputs help to determine whether a collision is unavoidable. On models equipped with Adaptive Variable Suspension PCS switches the suspension setting to sport mode to help provide appropriate chassis response, preemptively retracts front seat belts, and pre-initializes BA so that increased braking will be applied the instant the driver depresses the pedal. The active-braking feature will automatically apply the brakes up to a deceleration rate of 0.3 g if the driver fails to react to system warnings.