See also:

Immobilizer system
The vehicle's keys have built-in transponder chips that prevent the hybrid system from starting if the key has not been previously registered in the vehicle's on-board computer. Never leave the key ...

If you lose your keys
New genuine Lexus keys can be made by your Lexus dealer using the other keys and the key number stamped on your key number plate. ...

Items to initialize
After reconnecting or performing maintenance on the battery, the following items must be initialized for normal system operation. ...