Lexus designed the 2010 GX 460 to combine function and elegance, with unmistakable brand identity rooted in the L-finesse design language. The overall effect conveys the vehicle's full-range capability and luxury credentials. A key goal of the designers was to have the vehicle create the impression of being sculpted from a single block of metal.

The distinctive grille features three horizontal bars and, upon closer inspection, intricate detail and texture that conveys renowned Lexus attention to detail. Distinctive character lines on the hood and a chrome surround frame the grille. The front bumper features standard integrated fog lamps.

Functional design elements include low-profile roof rails and an acoustic insulation windshield that help reduce wind noise. Tasteful luxury touches abound, including green-tint UV protection front glass, privacy glass on rear windows, and running board courtesy lamps.