Ultra-premium wood, polished-metal accents and leather trim endow the GS interior with a lavish yet high-precision feel. Touch points convey quality and controls that respond fluidly. The customer can choose from among three interior leather color combinations: Light Gray leather with Dark Gray Bird's-eye maple wood trim, Parchment leather with Golden Bird's-eye Maple wood trim, or Black leather with Red Walnut wood trim. Each combination includes a matching wood and leather-trim steering wheel and shift knob that is standard on Lexus GS 460 and optional on GS 350.

Lexus designers strive to keep controls simple and intuitive, avoiding needless complexity. The SmartAccess keyless entry and push-to-start ignition allow the driver to keep the access fob in a pocket or purse. Audio and climate-control systems are easy to understand and operate. The unique instrument panel lighting system relies on variable-transparency glass to minimize reflections from the gauge faces and to help optimize visibility in all lighting conditions.