The standard Regency leather-trimmed, heated, 10-way power front seats (perforated leather trim on Lexus GS 460) are comfortably contoured for support on long trips. Ventilated front seats are standard for the GS 460 and available for the Lexus GS 350. A power-tilt and telescopic steering wheel helps ensure a comfortable driving position. The standard dual-zone climate-control system filters the air. An optional rear power sunshade may add to passenger comfort on warm days.

All four windows offer one-touch up-and-down operation with jam protection. Both electrochromic auto-dimming side mirrors are power-retractable and feature automatic tilt-down to aid in parking when reverse gear is selected. A power trunk closer provides an added convenience on this extremely well-equipped car.

The standard Lexus Premium Audio System features a six-disc, in-dash CD changer, iPod/USB connectivity, Bluetooth® hands free phone and music streaming, and integrated XM® satellite radio receiver. The system plays through 10 premium speakers while an Automatic Sound Levelizer (ASL) maintains consistent sound levels at varying vehicle speeds.