The GS gas luxury sport sedan comes in three models - GS 350 RWD, GS 350 AWD and GS 460 RWD. Optimized for low internal friction, the GS 350's 3.5-liter V6 engine produces 303 horsepower at 6,200 rpm and 274 lb.-ft. of peak torque at 3,600 rpm. A direct fuel-injection system provides much finer fuel-mixture control to improve both power and fuel efficiency. Dual Variable Valve Timing with intelligence (VVT-i) acts on both intake and exhaust valves to further enhance performance through a wide rpm range. A smooth-shifting six-speed transmission allows sequential shifting when desired.

The Lexus GS 460's V8 produces 342 horsepower at 6,400 rpm and 339 lb.-ft. of peak torque at 4,100 rpm. The GS 460, like the Lexus GS 350, meets the EPA's Ultra Low Emission Vehicle (ULEV-II) certification. Lexus has been setting standards for powertrain smoothness since its inception, and the GS 460's V8 and eight-speed automatic transmission continue that tradition. The transmission, like the six-speed automatic in the Lexus GS 350 models, allows manual shifting for a more engaging driving experience, and helps to maximize performance in certain driving situations. The Lexus GS 460 can accelerate from zero to 60 mph in 5.4 seconds, the Lexus GS 350 in 5.7 (5.8 for AWD).