The Lexus ES 350 owes its smooth, quiet ride in large part to a rigid unibody structure that allows the four-wheel independent suspension to be tuned to provide responsive handling agility and ultra-smooth ride quality. The low 0.28 coefficient of drag (Cd) helps minimize wind noise while also helping to maximize highway fuel efficiency. Standard 17 x 7-inch aluminum alloy wheels with a new split five-spoke design carry 215/55R17 all-season tires. A full-size spare wheel/tire is available.

Standard Vehicle Stability Control (VSC) with traction control system integrates the Anti-lock Braking System (ABS), Electronic Brake-force Distribution (EBD) and the Brake Assist (BA) safety feature. A new VSC cut-off switch for 2010 is useful if it becomes necessary to extricate the car from deep snow or other difficult conditions, such as mud or sand.