The Lexus ES 350's aluminum 3.5-liter V6 produces 272 horsepower at 6,200 rpm and 254 lb.-ft. peak torque at 4,700 rpm. The chain-driven camshafts employ Dual Variable Valve Timing with intelligence (Dual VVT-i) for optimal performance and efficiency at all engine speeds.

The six-speed automatic Electronically Controlled Transmission with intelligence (ECT-i) provides a sequential manual shift feature for a more involved driving experience when desired. Shifting strategy adapts to driver input, with rapid kick-down response.