Introduced for the 2006 model year, the present-generation IS 250 represents the second iteration of the Lexus IS series. These earlier cars are pretty much the same as the current model, though there have been a few changes along the way. For 2009, Lexus restyled the grille, retuned the suspension and added a two-tone interior option. For 2010, there were a number of technology upgrades including a new iPod interface, enhanced Bluetooth and a hard-drive-based navigation system (compared to the earlier DVD-based unit).

The first generation, known as the IS 300 was sold from 2001-'05. This car was quicker and more involving to drive than today's IS 250, but it wasn't as roomy, refined or nearly as luxurious, with its cabin being more reminiscent of a lower-line Toyota than a Lexus.